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MSQC1 Sigma-Aldrich

MS Qual/Quant QC Mix

Proteomics MRM LC-MS Calibration Standard

  •  NACRES NA.24

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Properties

Related Categories Mass Spectrometry, Molecular Biology, Peptide and Protein Standards for Mass Spectrometry Analysis, Proteomics
Quality Level   200
form   solid
quality   Proteomics MRM LC-MS Calibration Standard
storage temp.   −20°C

Description

Application

This product is optimized to assess platform characteristics, including:
• Repeatability/Reproducibility between runs
• System stability (drift, chromatography, signal intensity, sensitivity, etc.)
• Inter- and intra- platform and lab comparisons

To view a poster by Tobias Kockmann and colleagues at ETH Zurich on the use of MSQC1 in multiple LC-MS platforms, please visit this poster link.

Features and Benefits

General

Complexity
• Defined mixture gives confidence in your instruments analysis

Qualitative

Mixture of 6 tryptically digested human proteins (FASTA file)
• Low complexity, defined mixture
• 25 fold concentration range
• C18 purified

14 SIL peptides
• SIL peptides span a concentration range greater than three orders of magnitude (Table 1)
• 2 - 3 peptides per protein

Quantitative

• MRM settings provided Skyline, xls, csv
• MRM transitions provided (files above)
• Light : Heavy ratios from 50:1 to 1:5

Components

Each vial contains 6 pre-digested (trypsin) human proteins plus 14 corresponding stable isotope labeled (SIL) peptides (7-8 μg total dried in a 0.5 mL vial).

Quality

Up to 100 uses based upon the recommended reconstitution method

Legal Information

This product is licensed under U.S. Patent No. 7,396,688 and foreign counterparts from E. I. du Pont de Nemours and Company. The purchase of this product conveys to the buyer the nontransferable right to use the purchased amount of the product for research and development only, including services for a third party for consideration. The buyer cannot sell or otherwise transfer this product, its components or materials made using this product or its components to a third party. Information about licenses for excluded uses is available from: E. I. du Pont de Nemours and Company; Attn: Associate Director, Commercial Development; DuPont Experimental Station E268; 200 Powdermill Rd.; Wilmington, DE 19803; 1-877-881-9787 (voice), 1-302-695-1437 (fax), licensing@dupont.com.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

MSQC1 and MRM/SRM: The ProteoRed Multicentric Experiment 8 Study (Poster)

1 Proteomics Laboratory, Vall d’Hebron Institute of Oncology (VHIO) Vall d’Hebron University Hospital, 08035 Barcelona, Spain 2 Centro Nacional de Biotecnologia‐CSIC, Madrid, Spain 3 Sigma‐Aldrich, S...
Francesc Canals1, Joan‐Josep Bech‐Serra1, Núria Colomé‐Calls1, Salvador Martínez‐Bartolomé2, Jim J. Walters3, Kevin B. Ray3, Juan‐Pablo Albar2, ProteoRed‐ISCIII Consortium4

Keywords: Cell disruption, Clinical, Mass spectrometry, Oncology, Proteomics

Related Content

Stable Isotope-labeled MS Internal Standards

What happens when you combine state-of-the-art technology with scientific prowess? Full-length protein standards with the highest purity and isotopic incorporation in the industry. Stable isotope-lab...
Keywords: Atomic absorption spectroscopy, Buffers, Digestions, Mass spectrometry, PAGE, Phosphorylations

Peer-Reviewed Papers
15

References

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MSRT1 MS RT Calibration Mix, Proteomics Retention Time Standard for LC-MS MSRT1 is a different kind of MS calibration standard.

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Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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