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52777-U Supelco

SupelMIP® SPE - Aminoglycosides

bed wt. 50 mg, volume 3 mL, pk of 50

  •  NACRES NB.21

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Properties

Related Categories Analytical/Chromatography, Sample Preparation & Purification, Solid Phase Extraction (SPE), SupelMIP Molecular Imprinted Polymers, SupelMIP SPE - Aminoglycosides More...
composition   bed wt., 50 mg
packaging   pk of 50
volume   3 mL
matrix active group   SupelMIP® phase

Description

General description

The SupelMIP SPE line consist s of highly cross-linked polymers that are engineered to extract a single analyte of interest or a class of structurally related analytes with an extremely high degree of selectivity. This is possible because selectivity is introduced during MIP synthesis in which a template molecule, designed to mimic the analyte, guides the formation of specific cavities or imprints that are sterically and chemically complementary to the analyte(s) of interest.

By careful design of the imprinting site, either by molecular modeling, experimental design, or screening methods, the binding cavities can be engineered to offer multiple interaction points with the analyte(s) of interest. This leads to a stronger interaction between the solid-phase and the analyte(s). As a consequence, harsher wash conditions can be tolerated during SPE methodology resulting in cleaner extracts. Because extraction selectivity is significantly improved, lower background is observed allowing analysts to achieve lower limits of detection.

Visit www.sigma-aldrich.com/supelmip to learn more.

Application

Developed for the class-selective extraction of aminoglycoside antibiotics from cell culture, honey, and animal tissue matrices

The aminoglycosides that have been tested include: dihydrostreptomycin, streptomycin, tobramycin, kanamycin, amikacin, gentamicin, neomycin, apramycin, spectinomycin and hygromycin B.

Features and Benefits

• Highly selective SPE for trace analysis in complex matrices
• Achieve lower detection limits
• Significant time and cost savings
• Improved MS-compatibility

Legal Information

SupelMIP is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Aminoglycoside Analysis in Pork Muscle using Molecularly Imprinted Polymer Cleanup and LC/MS/MS Detection

Aminoglycosides are a well-known class of antibiotics that are routinely monitored in animal-derived foods. Many countries have instituted regulatory limits for aminoglycosides. There is growing conc...
Emily Barrey, Olga Shimelis, K. G. Espenschied
Reporter US, Volume 32.2
Keywords: Antibiotics, High performance liquid chromatography, Mass spectrometry, Separation, Size-exclusion chromatography, Solid phase extractions

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Solid Phase Extraction: Fundamentals and Recent Developments [Webinar]

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