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900848 Sigma-Aldrich

4-Amino-2-trimethylsilanylethynyl-benzenesulfonyl fluoride

Synonym: Amino sulfonyl fluoride TMS-alkyne, Probe building block

  • CAS Number 2088828-95-7

  • Empirical Formula (Hill Notation) C11H14FNO2SSi

  • Molecular Weight 271.38

  •  NACRES NA.22

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Conjugation Chemistry: Azides, Alkynes and Other Reagents, Copper Click Chemistry, Trifunctional Probe Building Blocks More...
Quality Level   100
storage temp.   −20°C
SMILES string   NC1=CC=C(S(=O)(F)=O)C(C#C[Si](C)(C)C)=C1

Description

Other Notes

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Application

Used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and amine synthetic handle. When appended to a ligand or pharmacophore through its amine linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Safety & Documentation

Safety Information

Symbol 
GHS02  GHS02
Signal word 
Danger
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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900598 (4-(Bromomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900599 (4-(Aminomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, 95%
900600 3-(Fluorosulfonyl)-5-((trimethylsilyl)ethynyl)benzoic acid, ≥95%
900601 3-Formyl-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900602 4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid, ≥95%
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900615 (4-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900614 3-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid, ≥95%
900613 5-(4-(4-(Prop-2-yn-1-yloxy)benzoyl)phenoxy)pentanoic acid, ≥95%
900611 (3-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900610 Hydroxyl di-benzophenone (PEG)3 alkyne
900617 (4-(Hydroxymethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone, ≥95%
900619 4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzaldehyde, ≥95%
900618 3-(3-(Bromomethyl)-5-ethynylphenyl)-3-(trifluoromethyl)-3H-diazirine, 95%
900683 2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)ethan-1-amine, 95%
900847 4-(Fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid, ≥95%
900858 2-(Prop-2-yn-1-yloxy)-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzoic acid, ≥95%
900860 3-Amino-5-ethynylbenzenesulfonyl fluoride, ≥95%
900862 (4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)-2-((trimethylsilyl)ethynyl)phenyl)methanol
900859 3-Bromo-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900863 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, ≥95%
900864 4-(Bromomethyl)-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%
900865 4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%

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