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902535 Sigma-Aldrich

Amino-PEG4-t-butyl ester

Synonym: tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, H2N-PEG4-CH2CH2COOtBu, H2N-dPEG(4)-CO-OtBu

  • CAS Number 581065-95-4

  • Empirical Formula (Hill Notation) C15H31NO6

  • Molecular Weight 321.41

  •  MDL number MFCD11041116

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Properties

Related Categories Bifunctional Linkers, Chemical Biology, Chemical Synthesis, Linkers and Crosslinkers
form   liquid
reaction suitability   reagent type: cross-linking reagent
refractive index   n/D 1.4508
density   1.04479 g/mL
storage temp.   −20°C

Description

Other Notes

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Development of Substrate-Selective Probes for Affinity Pulldown of Histone Demethylases

A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination

Application

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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901830 Pomalidomide-PEG4-NH2 hydrochloride, ≥95%
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902659 Amino-PEG6-t-butyl ester
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