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  • 902535 - Amino-PEG4-t-butyl ester

902535 Sigma-Aldrich

Amino-PEG4-t-butyl ester

Synonym: tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, H2N-PEG4-CH2CH2COOtBu, H2N-dPEG(4)-CO-OtBu

  • CAS Number 581065-95-4

  • Empirical Formula (Hill Notation) C15H31NO6

  • Molecular Weight 321.41

  •  MDL number MFCD11041116



Related Categories Bifunctional Linkers, Chemical Biology, Chemical Synthesis, Linkers and Crosslinkers
form   liquid
reaction suitability   reagent type: cross-linking reagent
refractive index   n/D 1.4508
density   1.04479 g/mL
storage temp.   −20°C


Other Notes

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This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


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