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902551 Sigma-Aldrich

BocNH-PEG4-acid

Synonym: 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH2COOH

  • CAS Number 876345-13-0

  • Empirical Formula (Hill Notation) C15H29NO8

  • Molecular Weight 351.39

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Properties

Related Categories Bifunctional Linkers, Chemical Biology, Chemical Synthesis, Linkers and Crosslinkers
form   liquid
reaction suitability   reagent type: cross-linking reagent
refractive index   n/D 1.4641
density   1.1395 g/mL
storage temp.   −20°C

Description

Other Notes

A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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