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902659 Sigma-Aldrich

Amino-PEG6-t-butyl ester

Synonym: tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate, H2N-PEG6-CH2CH2COOtBu

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Properties

Related Categories Bifunctional Linkers, Chemical Biology, Chemical Synthesis, Linkers and Crosslinkers
form   liquid
reaction suitability   reagent type: cross-linking reagent
refractive index   n/D 1.4562
density   1.06581 g/mL
storage temp.   −20°C

Description

Application

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Description

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901832 Pomalidomide-PEG6-NH2 hydrochloride, ≥98%
901829 Pomalidomide-PEG6-CO2H
901860 (S,R,S)-AHPC-PEG6-NH2 hydrochloride, ≥95%
902527 Amino-PEG5-t-butyl ester, ≥95%
902535 Amino-PEG4-t-butyl ester
905208 Pomalidomide-C6-PEG3-butyl amine hydrochloride, ≥98%
907677 (S,R,S)-AHPC-PEG6-butyl chloride
910023 3,6,9,12,15,18-Hexaoxahexacos-25-ynoic acid
910074 27,27-Dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid, ≥95%

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