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  • 909351 - (S,R,S)-AHPC-PEG5-azide

909351 Sigma-Aldrich



Synonym: (2S,4R)-1-((S)-20-Azido-2-(tert-butyl)-4-oxo-6,9,12,15,18-pentaoxa-3-azaicosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate

  • Empirical Formula (Hill Notation) C34H51N7O9S

  • Molecular Weight 733.88



Related Categories Chemical Biology, Chemical Synthesis, Degrader Building Blocks, Degrader Building Blocks for Click Chemistry
assay   ≥98%
form   (Liquid or Semi-Solid or Paste or Solid)
reaction suitability   reaction type: click chemistry
storage temp.   2-8°C


Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs


Protein degrader builiding block (S,R,S)-AHPC-PEG5-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with an alkyne on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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910007 20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid, 95%
910015 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid, ≥95%
911801 AHPC-C6-PEG1-C3-PEG1-butyl amine hydrochloride, ≥90%
911690 C5 Lenalidomide, ≥95%
911666 Pomalidomide-C6-NH2 hydrochloride, ≥95%
911658 Pomalidomide-C3-NH2 hydrochloride, ≥95%
913987 Pomalidomide-C6-PEG1-C3-PEG1-butyl amine hydrochloride, ≥95%
915572 Pomalidomide-dipiperazine-NH2 hydrochloride, ≥95%

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