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  • 910007 - 20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid

910007 Sigma-Aldrich

20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid


Synonym: Azido-PEG6-CH2CO2H, Azido-PEG6-acid, N3-PEG6-CH2COOH

  • CAS Number 880129-82-8

  • Empirical Formula (Hill Notation) C14H27N3O8

  • Molecular Weight 365.38



Related Categories Azide (-N3) Functionalized, Azide-PEG-Hydroxyl (N3-PEG-OH), Bifunctional Linkers, Chemical Biology, Chemical Synthesis,
assay   95%
form   (Liquid or Semi-Solid or Paste or Solid)
reaction suitability   reagent type: cross-linking reagent
storage temp.   2-8°C


Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation


This heterobifunctional, PEGylated crosslinker 20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG6-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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