• USA Home
  • 910058 - 2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid

910058 Sigma-Aldrich

2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid


Synonym: 2-2-6 PROTAC® linker, Alkyne-PEG2-acid, Bifunctional linker

  • Empirical Formula (Hill Notation) C12H20O4

  • Molecular Weight 228.28



Related Categories Bifunctional Linkers, Chemical Biology, Chemical Synthesis, Linkers and Crosslinkers
assay   ≥95%
form   (Viscous Liquid or Semi-solid or Paste or Solid)
storage temp.   2-8°C


Other Notes

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation


This heterobifunctional, PEGylated crosslinker 2-(2-(oct-7-yn-1-yloxy)ethoxy)acetic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG2-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.


Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Related Products

related product

Product #


Add to Cart

901577 t-Boc-N-amido-PEG2-CH2CO2H, ≥95%
901572 Bromo-PEG2-acid, ≥95%
901566 Propargyl-PEG2-acid
904724 Pomalidomide-PEG2-butyl iodide, ≥95%
904872 Pomalidomide-PEG2-butyl azide, ≥95%
905216 (S,R,S)-AHPC-PEG2-butyl azide, ≥95%
905399 (S,R,S)-AHPC-PEG2-butyl chloride
906123 (S,R,S)-AHPC-PEG2-butyl amine hydrochloride
910023 3,6,9,12,15,18-Hexaoxahexacos-25-ynoic acid
910066 6-(2-(2-(Oct-7-yn-1-yloxy)ethoxy)ethoxy)hexanoic acid, ≥90%
910074 27,27-Dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid, ≥95%
909998 2-(2-((7-(tert-Butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid, ≥95%

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?