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910066 Sigma-Aldrich

6-(2-(2-(Oct-7-yn-1-yloxy)ethoxy)ethoxy)hexanoic acid

New

≥90%

Synonym: 6-2-2-6 PROTAC® linker, Alkyne-PEG3-acid, Bifunctional linker

  • Empirical Formula (Hill Notation) C18H32O5

  • Molecular Weight 328.44

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Properties

Related Categories Chemical Biology, Chemical Synthesis, New Products for Chemical Synthesis More...
assay   ≥90%
form   liquid
storage temp.   2-8°C

Description

Other Notes

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

Application

This heterobifunctional, PEGylated crosslinker 6-(2-(2-(oct-7-yn-1-yloxy)ethoxy)ethoxy)hexanoic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG3-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation where the linker region is referred to as 6-2-2-6.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

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