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913979 Sigma-Aldrich

Biotin-Thalidomide

New

≥95%

Synonym: N1-(4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-N5-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide, Biotin-conjugated thalidomide, bio-Thal

  • CAS Number 2230857-87-9

  • Empirical Formula (Hill Notation) C44H64N8O13S

  • Molecular Weight 945.09

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Properties

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Quality Level   100
assay   ≥95%
form   powder
storage temp.   −20°C

Description

Other Notes

The dTAG system for immediate and target-specific protein degradation

Application

Biotin-Thalidomide (bio-Thal) is a cereblon affinity probe for PROTAC® and targeted protein degradation research. Bio-Thal can be used in cereblon (CRBN) binding and displacement assays for protein degrader validation experiments, CRBN ligand discovery, competition analyses, or where enrichment of CRBN complexes is required.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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