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KITALYSISBASE Sigma-Aldrich

KitAlysis High-Throughput Base Screening Kit - Pack of 2

Synonym: Base screen, Base screening kit, KitAlysis base

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Description

Application

Versatile base screening kit for cross-coupling reactions and other synthetic transformations. Step-by-step user guide and a downloadable experimental excel sheet are provided in the below hyperlinks.
Step-by-Step Guide for KitAlysis High-Throughput Base Reaction Screening Kit
Excel spreadsheet hyperlink

Each kit contains 2 customizable screening sets that contain the following:
• 7 X 2 pre-weighed bases (30 μmol) in individual microvials with magnetic stir bars
• 4 X 2 base solutions
• 2 empty microvials for Chemist′s Choice of base allowing customization
• 4 degassed anhydrous solvents (DMF, MeOH, THF, Toluene)
• 2 NEW KitAlysis 24-Well Reaction Block Replacement Films
• 4 empty substrate stock solution reaction vials with stirbars

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

• Designed and tested by synthetic chemists
• Easily run 24-microscale reactions in parallel
• 10 μmol reactions with 3 equiv. base, 0.1 M concentration
• Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit component also available separately

Description

Product #

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Potassium phosphate tribasic, anhydrous, free-flowing, Redi-Dri, reagent grade, ≥98% SDS RDD019
Potassium bicarbonate, ACS reagent, 99.7%, powder, crystals or granules    
Cesium carbonate, ReagentPlus®, 99% SDS 441902
Potassium hydroxide, anhydrous, ≥99.97% trace metals basis SDS 757551
Potassium acetate, anhydrous, free-flowing, Redi-Dri, ACS reagent, ≥99.0% SDS 791733
1,8-Diazabicyclo[5.4.0]undec-7-ene, 98% SDS 139009
Lithium bis(trimethylsilyl)amide solution, 1.0 M in THF SDS 225770
Sodium tert-butoxide solution, 2 M in THF, ZerO2® SDS 702706
Toluene, anhydrous, ZerO2®, 99.8% SDS 900522
Triethylamine, ZerO2®, ≥99% SDS 900632
Tetrahydrofuran, anhydrous, inhibitor-free, ZerO2®, ≥99.9% SDS 900636
N,N-Dimethylformamide, anhydrous, ZerO2®, 99.8% SDS 900638
Methanol, anhydrous, ZerO2®, 99.8% SDS 900641
Spinbar® magnetic stirring fleas, red, L × diam. 10 mm × 3 mm SDS Z118850
KitAlysis 24-well reaction block replacement film SDS Z742110
Potassium carbonate, anhydrous, free-flowing, Redi-Dri, ReagentPlus®, 99% SDS 900501
Sodium hydroxide, reagent grade, 97%, powder SDS 655104
Safety & Documentation

Safety Information

RIDADR 
UN 3316 9
Protocols & Articles

Articles

KitAlysis™ 24-Well Reaction Block and Screwdriver Set

KitAlysis™ 24-Well Reaction Block KitAlysis™ Torque Screwdriver set KitAlysis™ Reaction Block Replacement Screws (10)
Keywords: Coupling reactions, Cross couplings

KitAlysis™ Benchtop Inertion Box

The Aldrich® KitAlysis™ Benchtop Inertion Box provides an inert environment to run oxygen sensitive cross-coupling reactions easily and robustly in a laboratory fume hood.
Keywords: Coupling reactions, Cross couplings

KitAlysis™ High-Throughput Base Reaction Screening Kit

The screening sets come pre-loaded with 30 µmol of base in each vial according to the following design.
Keywords: Coupling reactions, Cross couplings, High performance liquid chromatography, Ligands, Solvents

KitAlysis™ High-Throughput Screening Platform

In the high-pressure environment of discovery chemistry, time is everything. While general catalytic methods exist, substrate dependency makes it difficult to predict optimal conditions in practice. ...
Keywords: Catalysis, Chemical reactions, Solvents

Protocols

Protocol KitAlysis™ High-Throughput Base Reaction Screening Kit

7 pre-weighed bases 4 base solutions (DBU (neat), Et3N (neat), LiHMDS (1.0 M in THF), and NaOtBu (2.0 M in THF)) 4 solvents (MeOH, Toluene, DMF, and THF)
Keywords: Addition reactions, High performance liquid chromatography, Ligands, PAGE, Solvents, Thin layer chromatography

Related Content

Catalysis for Screening: KitAlysis™ [VIDEO]

Take a quick look at our latest technology. Now any chemist can quickly and efficiently screen 24 unique cross-coupling reaction conditions with an off-the-shelf kit designed by leading global pharma...
Keywords: Coupling reactions, Cross couplings, PAGE

KitAlysis™ High-Throughput Screening Kits: A Visual Introductory Guide [VIDEO]

This KitAlysis™ High-Throughput Screening Kits video animation clearly illustrates the step by step process that enables any chemist to quickly and efficiently screen 24 unique cross-coupling reactio...
Keywords: Coupling reactions, Cross couplings

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