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KITALYSIS-CN Sigma-Aldrich

KitAlysis High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

Synonym: Amination Screening Kit, Buchwald-Hartwig Amination

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Description

Application

Screening kit for CN (Buchwald-Hartwig) cross-coupling reaction. There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.
Two Solvents, Weak Base (Cs2CO3)
Two Solvents, Strong Base (NaOt-Bu)
One Solvent (Dioxane), Two Bases
One Solvent (DMAc), Two Bases
Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains
• 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
• 2 bases (NaOt-Bu and Cs2CO3)
• 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
• 2 substrate reaction vials with stir bars
• 1 internal standard
• 4 reaction block replacement films

this protocol

Best when used with KitAlysis Benchtop Inertion Box
and 24-well Reaction Block
(sold separately).

Features and Benefits

• Designed and tested by synthetic chemists
• Easily run 24-microscale reaction in parallel
• 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
• Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit component also available separately

Description

Product #

Add to Cart

N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mL SDS 900634
1,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mL SDS 900640
Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mL SDS 702706
Josiphos SL-J009-1 Pd G3 5 µmol SDS 747130
SPhos Pd G2 5 µmol SDS 753009
RuPhos Pd G2 5 µmol SDS 753246
P(t-Bu)3 Pd G2 5 µmol SDS 756482
BrettPhos Pd G3, 95% 5 µmol SDS 761605
tBuXPhos Pd G3, 95% (dried basis) 5 µmol SDS 762229
CPhos Pd G3, 95% 5 µmol SDS 763004
XantPhos Pd G3, 95% 5 µmol SDS 763039
XPhos Pd G3, 95% 5 µmol SDS 763381
MorDalphos Pd G3 5 µmol SDS 792357
DavePhos-Pd-G3, 95% 5 µmol SDS 804959
rac-BINAP-Pd-G3, 95% 5 µmol SDS 804967
SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA SDS 94791
Safety & Documentation

Safety Information

RIDADR 
UN 3316 9
Protocols & Articles

Articles

KitAlysis High-Throughput Copper C-N Cross-Coupling Reaction Screening Kit

The screening sets come pre-loaded with 4 µmol of ligand in each vial according to the following design.  
Keywords: Cross couplings, High performance liquid chromatography, Ligands

KitAlysis High-Throughput Palladium Precatalyst Cross-Coupling Reaction Screening Kit

The screening sets come pre-loaded with 1 µmol of catalyst in each vial according to the following design.  
Keywords: Coupling reactions, Cross couplings, High performance liquid chromatography

KitAlysis™ 24-Well Reaction Block and Screwdriver Set

KitAlysis™ 24-Well Reaction Block KitAlysis™ Torque Screwdriver set KitAlysis™ Reaction Block Replacement Screws (10)
Keywords: Coupling reactions, Cross couplings

KitAlysis™ Benchtop Inertion Box

The Aldrich® KitAlysis™ Benchtop Inertion Box provides an inert environment to run oxygen sensitive cross-coupling reactions easily and robustly in a laboratory fume hood.
Keywords: Coupling reactions, Cross couplings

KitAlysis™ C-N (Buchwald-Hartwig) High-Throughput Screening Kit

The screening sets come pre-loaded with 1 µmol of catalyst in each vial according to the following design.
Keywords: Cross couplings, High performance liquid chromatography, Ligands, Solvents

KitAlysis™ High-Throughput Screening Platform

In the high-pressure environment of discovery chemistry, time is everything. While general catalytic methods exist, substrate dependency makes it difficult to predict optimal conditions in practice. ...
Keywords: Catalysis, Chemical reactions, Solvents

Scale-Up Guide: Buchwald-Hartwig Amination Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form. Once activated by base under the reaction conditions they become sensitive t...
Keywords: Coupling reactions, Cross couplings, Solvents

Protocols

One Solvent (DMAc), two bases (NaOtBu, Cs2CO3) Step-by-Step Guide for Buchwald-Hartwig Amination Reaction Screening Kit

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.
Keywords: Addition reactions, Aminations, Buchwald-Hartwig amination, High performance liquid chromatography, PAGE, Thin layer chromatography

One Solvent (Dioxane), two bases (NaOtBu, Cs2CO3) Step-by-Step Guide for Buchwald-Hartwig Amination Reaction Screening Kit

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.
Keywords: Addition reactions, Aminations, Buchwald-Hartwig amination, High performance liquid chromatography, PAGE, Thin layer chromatography

Two solvents (Dioxane, DMAc), strong base (NaOt-Bu) Step-by-Step Guide for Buchwald-Hartwig Amination Reaction Screening Kit

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.
Keywords: Addition reactions, Aminations, Buchwald-Hartwig amination, High performance liquid chromatography, PAGE, Solvents, Thin layer chromatography

Two solvents (Dioxane, DMAc), weak base (Cs2CO3) Step-by-Step Guide for Buchwald-Hartwig Amination Screening Kit

1 base (Cs2CO3, ground and sieved) 2 solvents (1,4 Dioxane and DMAc) 12 pre-weighed catalysts
Keywords: Addition reactions, Aminations, Buchwald-Hartwig amination, High performance liquid chromatography, PAGE, Solvents, Thin layer chromatography

Related Content

Catalysis for Screening: KitAlysis™ [VIDEO]

Take a quick look at our latest technology. Now any chemist can quickly and efficiently screen 24 unique cross-coupling reaction conditions with an off-the-shelf kit designed by leading global pharma...
Keywords: Coupling reactions, Cross couplings, PAGE

KitAlysis™ High-Throughput Screening Kits: A Visual Introductory Guide [VIDEO]

This KitAlysis™ High-Throughput Screening Kits video animation clearly illustrates the step by step process that enables any chemist to quickly and efficiently screen 24 unique cross-coupling reactio...
Keywords: Coupling reactions, Cross couplings

Peer-Reviewed Papers
15

References

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