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KitAlysis High-Throughput Copper C-N Cross-Coupling Reaction Screening Kit-Pack of 2

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Description

Application

Screening kit for Copper C-N Cross-Coupling Reactions. Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.

Step-by-Step Guide for KitAlysis High-Throughput Copper C-N Cross-Coupling Reaction Screening Kit

Each kit contains 2 customizable screening sets that include the following components:
• 24 (6 x 4) pre-weighed ligands in glass vials loaded with stir bars, topped with cap mat
• Potassium phosphate: 4 pre-weighed vials with product labels and lids
• CuI (soluble source) in preweighed vial
• 4 degassed anhydrous solvents (dioxane, DMAc, toluene, and DMSO) in ampules
• 1 internal standard
• 2 KitAlysis 24-Well reaction block replacement films
• 8 stir bars for stock solutions
• Ampule cracker

Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

Features and Benefits:
• Designed and tested by synthetic chemists.
• Easily run 24-microscale reaction in parallel.
• Suggested conditions: 10 μmol reactions with 1 μmol catalyst (10 mol%) 0.1 M concentration, and 3 equiv. base.
• Customizable and downloadable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks.

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
UN 3316 9
Protocols & Articles

Articles

KitAlysis High-Throughput Copper C-N Cross-Coupling Reaction Screening Kit

The screening sets come pre-loaded with 4 µmol of ligand in each vial according to the following design.  
Keywords: Cross couplings, High performance liquid chromatography, Ligands

KitAlysis™ 24-Well Reaction Block and Screwdriver Set

KitAlysis™ 24-Well Reaction Block KitAlysis™ Torque Screwdriver set KitAlysis™ Reaction Block Replacement Screws (10)
Keywords: Coupling reactions, Cross couplings

KitAlysis™ Benchtop Inertion Box

The Aldrich® KitAlysis™ Benchtop Inertion Box provides an inert environment to run oxygen sensitive cross-coupling reactions easily and robustly in a laboratory fume hood.
Keywords: Coupling reactions, Cross couplings

KitAlysis™ High-Throughput Screening Platform

In the high-pressure environment of discovery chemistry, time is everything. While general catalytic methods exist, substrate dependency makes it difficult to predict optimal conditions in practice. ...
Keywords: Catalysis, Chemical reactions, Solvents

Scale-Up Guide: Copper C-N Cross-Coupling Reaction

All of the catalysts used in the kit are sensitive to air and moisture in their commercially available form. Please see the catalyst MSDS or product detail page for details on handling and storage. T...
Keywords: PAGE, Solvents

Protocols

Protocol -KitAlysis High-Throughput Copper C-N Cross-Coupling Reaction Screening Kit

1 base (K3PO4, pre-weighed solid) 4 solvents (DMAc, Toluene, DMSO, and Dioxane) 6 pre-weighed ligands
Keywords: Addition reactions, Coupling reactions, Cross couplings, High performance liquid chromatography, Ligands, PAGE, Solvents, Thin layer chromatography

Related Content

Catalysis for Screening: KitAlysis™ [VIDEO]

Take a quick look at our latest technology. Now any chemist can quickly and efficiently screen 24 unique cross-coupling reaction conditions with an off-the-shelf kit designed by leading global pharma...
Keywords: Coupling reactions, Cross couplings, PAGE

KitAlysis™ High-Throughput Screening Kits: A Visual Introductory Guide [VIDEO]

This KitAlysis™ High-Throughput Screening Kits video animation clearly illustrates the step by step process that enables any chemist to quickly and efficiently screen 24 unique cross-coupling reactio...
Keywords: Coupling reactions, Cross couplings

KitAlysis™ High-Throughput Screening Kits

In the high-pressure environment of discovery chemistry, time is everything. While general catalytic methods exist, substrate dependency makes it difficult to predict optimal conditions in practice. ...
Keywords: Aminations, Asymmetric synthesis, Buchwald-Hartwig amination, Catalysis, Chemical reactions, Coupling reactions, Cross couplings, Hydrogenations, Ligands, Mass spectrometry, Materials Science, Metal scavengers, Metathesis, Miyaura Borylation Reaction, Size-exclusion chromatography, Thin layer chromatography

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