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KitAlysis High-Throughput Medium (5, 6, 7) Ring Closing Metathesis Reaction Screening Kit - Pack of 2

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Description

Application

Screening kit for ring closing metathesis. Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.
Step-by-Step Guide for Ring Closing Metathesis/Cross Metathesis Reaction Screening Kit Downloadable Experiment excel sheets

Each kit contains 2 customizable screening sets that include the following components:
• 6x4 pre-weighed catalysts in glass microvials loaded with stir bars and topped with cap mat.
• 2 (2 mL) ampules each of of ClPh, PhMe, i-PrOAc, Me-THF, and TFA.
• 1 KitAlysis 24-well reaction block replacement film.
• 4 empty substrate stock solution reaction vials with stir bars.
• 1 internal standard.

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

• Designed and tested by synthetic chemists.
• Easily run 24-microscale reaction in parallel.
• 20 μmol reactions with 1 μmol catalyst (5 mol%), 0.2 M concentration, and optional TFA additive.
• Customizable and downloadable excel template for quick calculations and easy incorporation into electronic laboratory notebooks.

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit component also available separately

Description

Product #

Add to Cart

Grubbs Catalyst® 2nd Generation 3 µmol SDS 569747
Hoveyda-Grubbs Catalyst® 2nd Generation, 97% 3 µmol SDS 569755
Grubbs Catalyst® 1st Generation, 97% 3 µmol SDS 579726
Grubbs Catalyst® C827 3 µmol SDS 682365
Grubbs Catalyst® C571 3 µmol SDS 682373
Grubbs Catalyst® C711 3 µmol SDS 729345
Isopropyl acetate, anhydrous, ZerO2®, ≥99.6% 8 mL SDS 900519
2-Methyltetrahydrofuran, BioRenewable, anhydrous, contains 250 ppm BHT as stabilizer, ZerO2®, ≥99.0% 8 mL SDS 900520
Chlorobenzene, anhydrous, ZerO2®, 99.8% 8 mL SDS 900521
Toluene, anhydrous, ZerO2®, 99.8% 8 mL SDS 900522
Spinbar® magnetic stirring fleas, red, L × diam. 10 mm × 3 mm 1 EA SDS Z118850
SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA SDS 94791
Safety & Documentation

Safety Information

RIDADR 
UN 3316 9
Protocols & Articles

Articles

KitAlysis™ 24-Well Reaction Block and Screwdriver Set

KitAlysis™ 24-Well Reaction Block KitAlysis™ Torque Screwdriver set KitAlysis™ Reaction Block Replacement Screws (10)
Keywords: Coupling reactions, Cross couplings

KitAlysis™ Benchtop Inertion Box

The Aldrich® KitAlysis™ Benchtop Inertion Box provides an inert environment to run oxygen sensitive cross-coupling reactions easily and robustly in a laboratory fume hood.
Keywords: Coupling reactions, Cross couplings

KitAlysis™ High-Throughput Screening Platform

In the high-pressure environment of discovery chemistry, time is everything. While general catalytic methods exist, substrate dependency makes it difficult to predict optimal conditions in practice. ...
Keywords: Catalysis, Chemical reactions, Solvents

Ring Closing Metathesis Reaction Screening Kit Materials

The screening sets come pre-loaded with 1 µmol of catalyst in each vial according to the following design.
Keywords: High performance liquid chromatography, Metathesis, Ring-closing metathesis

Scale-Up Guide: Medium (5, 6, 7) Ring Closing Metathesis

All of the catalysts used in the kit are sensitive to air and moisture in their commercially available form. Please see the catalyst SDS or product detail page for details on handling and storage. To...
Keywords: PAGE, Solvents

Protocols

Medium (5,6,7) Ring-Closing Metathesis Procedure

4 degassed solvents: Chlorobenzene (ClPh), Toluene (PhMe), Isopropyl Acetate (i-PrOAc), and Methyl-THF (Me-THF)
Keywords: Addition reactions, Cross metathesis, High performance liquid chromatography, Isomerizations, Metathesis, Olefin metathesis, Solvents, Thin layer chromatography

Related Content

Catalysis for Screening: KitAlysis™ [VIDEO]

Take a quick look at our latest technology. Now any chemist can quickly and efficiently screen 24 unique cross-coupling reaction conditions with an off-the-shelf kit designed by leading global pharma...
Keywords: Coupling reactions, Cross couplings, PAGE

KitAlysis™ High-Throughput Screening Kits: A Visual Introductory Guide [VIDEO]

This KitAlysis™ High-Throughput Screening Kits video animation clearly illustrates the step by step process that enables any chemist to quickly and efficiently screen 24 unique cross-coupling reactio...
Keywords: Coupling reactions, Cross couplings

Peer-Reviewed Papers
15

References

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