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KitAlysis High-Throughput Suzuki-Miyaura Cross-Coupling Reaction Screening Kit - Pack of 4

Synonym: Suzuki-Miyaura Cross-Coupling

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Description

Application

Screening kit for Suzuki-Miyaura cross-coupling reaction. Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.
Step-by-Step Guide for Suzuki-Miyaura Cross-Coupling Reaction Screening Kit
Downloadable Experiment excel sheets.

Each kit contains 4 customizable screening sets that include the following components:
• 6 x 4 pre-weighed catalysts in glass vials loaded with stir bars and topped with cap mat.
• 1 (2 mL) ampule each of Toluene, THF, n-Butanol, DMAc, and aq. 1.5 M K3PO4.
• 4 NEW KitAlysis 24-Well Reaction Block Replacement Films.
• 4 substrate reaction vials with stir bars.
• 1 internal standard.

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

• Designed and tested by synthetic chemists.
• Easily run 24-microscale reactions in parallel.
• 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration.
• Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks.

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit component also available separately

Description

Product #

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Pd-PEPPSI-IPent catalyst, ≥95% 5 µmol SDS 732117
SPhos Pd G2 5 µmol SDS 753009
cataCXium® A Pd G2 5 µmol SDS 761311
XPhos Pd G3, 95% 5 µmol SDS 763381
P(Cy3) Pd G3, 97% 5 µmol SDS 764175
APhos Pd G3, 97% 5 µmol SDS 764183
Toluene, anhydrous, ZerO2®, 99.8% 8 mL SDS 900522
Tetrahydrofuran, anhydrous, inhibitor-free, ZerO2®, ≥99.9% 8 mL SDS 900636
1-Butanol, anhydrous, ZerO2®, 99.8% 8 mL SDS 900639
N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mL SDS 900634
Degassed Potassium phosphate tribasic solution 8 mL    
Spinbar® magnetic stirring fleas, red, L × diam. 10 mm × 3 mm 1 EA SDS Z118850
SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA SDS 94791
Safety & Documentation

Safety Information

RIDADR 
UN 3316 9
Protocols & Articles

Articles

KitAlysis High-Throughput Palladium Precatalyst Cross-Coupling Reaction Screening Kit

The screening sets come pre-loaded with 1 µmol of catalyst in each vial according to the following design.  
Keywords: Coupling reactions, Cross couplings, High performance liquid chromatography

KitAlysis Suzuki-Miyaura Cross-Coupling Screening Kit

The screening sets come pre-loaded with 1 µmol of catalyst in each vial according to the following design.
Keywords: Cross couplings, High performance liquid chromatography, Ligands

KitAlysis™ 24-Well Reaction Block and Screwdriver Set

KitAlysis™ 24-Well Reaction Block KitAlysis™ Torque Screwdriver set KitAlysis™ Reaction Block Replacement Screws (10)
Keywords: Coupling reactions, Cross couplings

KitAlysis™ Benchtop Inertion Box

The Aldrich® KitAlysis™ Benchtop Inertion Box provides an inert environment to run oxygen sensitive cross-coupling reactions easily and robustly in a laboratory fume hood.
Keywords: Coupling reactions, Cross couplings

KitAlysis™ High-Throughput Screening Platform

In the high-pressure environment of discovery chemistry, time is everything. While general catalytic methods exist, substrate dependency makes it difficult to predict optimal conditions in practice. ...
Keywords: Catalysis, Chemical reactions, Solvents

Suzuki-Miyaura Cross-Coupling Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form. Once activated by base under the reaction conditions they become sensitive t...
Keywords: Coupling reactions, Cross couplings, Solvents

Protocols

Suzuki-Miyaura Cross-Coupling Screening Kit Protocol

1 base (K3PO4, 1.5 M solution in degassed water) 4 degassed solvents (DMAc, Toluene, n-Butanol, and THF) 6 pre-weighed catalysts (x4)
Keywords: Addition reactions, Coupling reactions, Cross couplings, High performance liquid chromatography, PAGE, Solvents, Thin layer chromatography

Related Content

Catalysis for Screening: KitAlysis™ [VIDEO]

Take a quick look at our latest technology. Now any chemist can quickly and efficiently screen 24 unique cross-coupling reaction conditions with an off-the-shelf kit designed by leading global pharma...
Keywords: Coupling reactions, Cross couplings, PAGE

KitAlysis™ High-Throughput Screening Kits: A Visual Introductory Guide [VIDEO]

This KitAlysis™ High-Throughput Screening Kits video animation clearly illustrates the step by step process that enables any chemist to quickly and efficiently screen 24 unique cross-coupling reactio...
Keywords: Coupling reactions, Cross couplings

Peer-Reviewed Papers
15

References

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