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A-096 Supelco

Aldosterone solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Synonym: 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-ene-3,18,20-trione, 18-Aldocorticosterone, Aldosterone, Reichstein X

  • CAS Number 52-39-1

  • Empirical Formula (Hill Notation) C21H28O5

  • Molecular Weight 360.44

  •  Beilstein/REAXYS Number 3224996

  •  EC Number 200-835-2

  •  MDL number MFCD00051136

  •  PubChem Substance ID 329770641

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Biomarkers and Metabolomics Standards, Certified Reference Materials (CRMs),
Quality Level   300
grade   certified reference material
feature   SNAP-N-SPIKE®, SNAP-N-SHOOT®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
concentration   100 μg/mL in acetonitrile
Featured Industry   Forensics and Toxicology
format   single component solution
storage temp.   −20°C
SMILES string   C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O
InChI   1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
InChI key   PQSUYGKTWSAVDQ-ZVIOFETBSA-N

Description

General description

Aldosterone is a hormone in the mineralocorticoid family which stimulates sodium transport across cell membranes and assists in the maintenance of blood pressure and blood volume. Aldosterone levels in serum/plasma and urine are measured by LC-MS/MS for investigation of primary or secondary aldosteronism ranging from adrenal cortical hyperplasia to renovascular disease and Bartter’s syndrome.

Other Notes

Exists as an equilibrium mixture of the aldehyde and the hemiacetal.

Application

The d-isomer of aldosterone is considered to be the biologically active isomer.

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1648 3 / PGII
WGK Germany 
WGK 2
Flash Point(F) 
35.6 °F - closed cup
Flash Point(C) 
2 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Hormone Standards

Over the past 17 years, hormone testing has increased significantly in the clinical laboratory setting as advances in the specificity and selectivity of LC-MS/MS technology have enabled hormones to s...
Keywords: Clinical, Clinical Chemistry, Diagnostic, Diseases, Endocrinology, High performance liquid chromatography, Hormones, Ion-exchange chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites

LC/MS/MS Analysis of Steroid Hormones in Plasma on Ascentis® Express C18 after Sample Prep using HybridSPE®-Phospholipid

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Steroid Hormones in Plasma on Ascentis® Express C18 after Sample Prep using HybridSPE®-Phospholipid
Keywords: Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Precipitation, Separation, Solid phase extractions, Solvents

LC/MS/MS Analysis of Steroid Hormones in Plasma

HybridSPE®-Phospholipid plates provided excellent analyte recovery of these difficult compounds from plasma samples with subsequent LC/MS/MS analysis on Ascentis® Express Fused-Core® C18 columns. The...
Craig Aurand
Reporter US Volume 32.2
Keywords: Clinical, High performance liquid chromatography, Hormones, Immunoassay, Liquid chromatography mass spectrometry, Mass spectrometry, Precipitation, Reductions, Sample preparations, Solid phase extractions

Peer-Reviewed Papers
15

References

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