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C-146 Supelco

Cholic acid

500 μg/mL in methanol, certified reference material, Cerilliant®

Synonym: 3α,7α,12α-Trihydroxy-5β-cholanic acid, Cholanic acid

  • CAS Number 81-25-4

  • Empirical Formula (Hill Notation) C24H40O5

  • Molecular Weight 408.57

  •  Beilstein/REAXYS Number 2822009

  •  EC Number 200-659-6

  •  MDL number MFCD00003672

  •  PubChem Substance ID 329774885

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Bile Acid Standards, Bile acids, Biomarkers and Metabolomics Standards,
Quality Level   300
grade   certified reference material
assay   99.9% (LC/MS)
feature   Snap-N-Spike®/Snap-N-Shoot®
packaging   ampule of 1 mL
mfr. no.   Cerilliant®
concentration   500 μg/mL in methanol
mp   200-201 °C (lit.)
format   single component solution
storage temp.   −20°C
SMILES string   [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@]([H])(CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(O)=O
InChI   1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
InChI key   BHQCQFFYRZLCQQ-OELDTZBJSA-N

Description

General description

This Certified Spiking Solution® is suitable as a starting material in preparation of linearity standards, calibrators, and controls for use in LC-MS/MS and GC/MS bile acid testing methods. Cholic acid is a primary bile acid that plays an important role in cholesterol homeostasis and intestinal absorption of dietary vitamins and lipids. Levels of cholic acid can serve as markers for inborn and acquired hepatobiliary disorders such as biliary atresia and familial intrahepatic cholestasis as well as inborn errors of bile acid synthesis and sclerosing cholangitis.

Application

Non-denaturing ionic detergent used for extraction of membrane proteins.

Biochem/physiol Actions

Bile Acid

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Eyes
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

HPLC Analysis of Bile Acids on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Bile Acids on Ascentis® Express C18
Keywords: Chromatography, Clinical, High performance liquid chromatography

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U-002 Ursodeoxycholic acid-D4, 100 μg/mL in methanol, certified reference material, Cerilliant®
C-147 Chenodeoxycholic acid-D4, 100 μg/mL in methanol, certified reference material, Cerilliant®
C-148 Cholic acid-D4, 100 μg/mL in methanol, certified reference material, Cerilliant®

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