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A6933 Sigma-Aldrich

Acetyl-Amyloid β-Protein Fragment 15-20 Amide

≥97% (HPLC), powder

Synonym: Ac-QKLVFF-NH2, amyloid blocker

  • CAS Number 189064-06-0

  • Empirical Formula (Hill Notation) C42H63N9O8

  • Molecular Weight 822.01

  •  MDL number MFCD17215285

  •  PubChem Substance ID 329770908

  •  NACRES NA.32

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Properties

Related Categories Alzheimer′s Disease, Amyloid Precursor Proteins and Fragments, Amyloid beta Protein Fragments, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   200
assay   ≥97% (HPLC)
form   powder
color   white
storage temp.   −20°C
SMILES string   CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(N)=O
InChI   1S/C42H63N9O8/c1-25(2)22-33(49-38(55)30(18-12-13-21-43)47-39(56)31(46-27(5)52)19-20-35(44)53)41(58)51-36(26(3)4)42(59)50-34(24-29-16-10-7-11-17-29)40(57)48-32(37(45)54)23-28-14-8-6-9-15-28/h6-11,14-17,25-26,30-34,36H,12-13,18-24,43H2,1-5H3,(H2,44,53)(H2,45,54)(H,46,52)(H,47,56)(H,48,57)(H,49,55)(H,50,59)(H,51,58)/t30-,31-,32-,33-,34-,36-/m0/s1
InChI key   DDXTVYDSGCHGAN-PITCCTKHSA-N
Gene Information   human ... APP(351)

Description

Amino Acid Sequence

Ac-Gln-Lys-Leu-Val-Phe-Phe-NH2

Packaging

1 mg in glass bottle

Biochem/physiol Actions

Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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