EMAIL THIS PAGE TO A FRIEND
L5025 Sigma-Aldrich

Leflunomide

Immunosuppressant

Synonym: 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide

  • CAS Number 75706-12-6

  • Empirical Formula (Hill Notation) C12H9F3N2O2

  • Molecular Weight 270.21

  •  MDL number MFCD00867593

  •  PubChem Substance ID 24278516

Purchase

Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, Dihydroorotate dehydrogenase,
Quality Level   200
assay   ≥98% (TLC)
form   powder
mp   166.5  °C
solubility   methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow
Mode of action   enzyme | inhibits
storage temp.   2-8°C
SMILES string   Cc1oncc1C(=O)Nc2ccc(cc2)C(F)(F)F
InChI   1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChI key   VHOGYURTWQBHIL-UHFFFAOYSA-N
Gene Information   human ... DHODH(1723)

Description

Application

By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation and treatment of rheumatoid arthritis and other autoimmune diseases.

Packaging

25, 100 mg in poly bottle

Biochem/physiol Actions

Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
RTECS 
NY2354200
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?