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SML1002 Sigma-Aldrich

Sinomenine hydrochloride

≥98% (HPLC)

Synonym: (9a,13a,14a)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one hydrochloride, Cucoline hydrochloride, Kukolin hydrochloride

  • CAS Number 6080-33-7

  • Empirical Formula (Hill Notation) C19H23NO4 · HCl

  • Molecular Weight 365.85

  •  MDL number MFCD01714307

  •  NACRES NA.77

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Properties

Related Categories Antioxidants and Cytoprotectants, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
biological source   plant (Sinomenium acutum)
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -70 to -90°, c = 1 in H2O
drug control   regulated under CDSA - not available from Sigma-Aldrich Canada
color   white to beige
solubility   H2O: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   OC1=C(OC)C=CC(C2)=C1[C@]3(CC(C(OC)=C4)=O)[C@@]4([H])[C@H]2N(C)CC3.Cl
InChI   1S/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13+,19-;/m1./s1
InChI key   YMEVIMJAUHZFMW-VUIDNZEBSA-N

Description

Biochem/physiol Actions

Sinomenine is a herbal medicine used to treat inflammatory diseases like rheumatoid arthritis. Sinomenine had anti-inflammatory effects in several animal models of inflammation, and inhibits mast cell degranulation and histamine release. Additionally, Sinomenine potentiates renewal of human embryonic stem cells.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
QD2163000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

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