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  • SRP5335 - PP2C-α, active, GST tagged human

SRP5335 Sigma-Aldrich

PP2C-α, active, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: FLJ42306, MGC9201, PP2C-ALPHA, PP2CA, PPM1A

  •  NACRES NA.32



Related Categories Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Tyrosine Phosphatase (TP), Tyrosine Phosphatase Biology More...
biological source   human
recombinant   expressed in baculovirus infected Sf9 cells
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   960-1440 nmol/min·mg
mol wt   ~105 kDa
application(s)   cell analysis: suitable
NCBI accession no.   NM_021003
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... PPM1A(5494)


General description

Protein phosphatase 2C-α (PP2C-α), also called protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A), is a member of the family of Ser/Thr protein phosphatases and is composed of a catalytic subunit and a constant regulatory subunit. PP2C-α is highly expressed in heart and skeletal muscle. The gene encoding this protein is localized on human chromosome 4q12.

Biochem/physiol Actions

Protein phosphatase 2C-α (PP2C-α) or PPM1A is known to be negative regulators of cell stress response pathways. It has been reported to negatively regulate TGF-β signaling pathway and cell cycle. PP2C-α has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control. It modulates cell migration and invasion. Overexpression of PP2C-α is reported to cause cell-growth arrest or cell death.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers


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