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575 matches found for building blocks

Building Blocks for Luminescent Materials

Material Matters 2009, 4.3, 57. Joe Porwoll, President Aldrich Chemical Co., Inc. Professor Koji Araki of the University of Tokyo kindly suggested that we offer 1,3,6,8-tetrabromopyrene (Aldrich Prod. No. 717274) as a building block for the synthesis of larger, luminescent materials. Molecules that ...

Natural Amino Acid Building Blocks for Peptide Synthesis

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.1 Today, the most common synthetic approaches to medium and even large peptides follow the Boc/Bzl or Fmoc/tBu solid phase peptide synthesis strategies.2 A convenient list of the ...

Building Block Explorer - Designed by Chemists for Chemists

Introducing Building Block Explorer We are building the industry’s most comprehensive source of truly available synthetic building blocks for use in chemical synthesis - all conveniently located within our website. Designed by Chemists for Chemists For synthetic and medicinal chemists who need to qu...

Trifunctional Probe Building Blocks

Related Articles • Chemical Synthesis Technology Spotlights Chemical probes that mimic a pharmacophore, ligand, or lead compound are of increasing interest for target identification and validation, protein profiling, imaging, or other applications in chemical biology. However, synthesis of the ideal...

Biocompatible Dendritic Building Blocks for Advanced Biomedical Research

Dendrimers and dendrons are symmetrically branched polymer structures that possess a well-defined spatial distribution of functional groups. These dendritic materials have attracted considerable interest due to their monodisperse nature and other unique properties such as enhanced solubility and red...

Ynamides: Versatile and Enabling Building Blocks for Chemical Synthesis

The development of original and versatile reagents in modern organic synthesis is of crucial importance for the design of new chemical transformations that enable the fast and efficient assembly of a variety of complex molecules. In this context, nitrogen-substituted alkynes, commonly named “ynamide...

Building Block Explorer FAQ

The new Building Block Explorer allows you to select and purchase our brand products as well as hundreds of thousands of our Supplier Partner Products. The Supplier Partner Products are reliable, high-quality chemistry products that are not available through the standard catalog. We formed partnersh...

NTz Building Blocks for Organic Semiconductors

Fax: +81-48-462-1473, E-mail: takimiya@riken.jp The field of organic electronics has emerged as the next-generation technology potentially enabling ultra-thin, large-area, and/or flexible devices, consisting of organic field-effect transistors (OFETs), organic light-emitting diodes (OLEDs), and orga...

Alkynes and Acetylenic Building Blocks

We list over 600 alkyne building blocks, including a wide array of propargyl alcohols, acetylenic boron reagents, and halogenated substrates for cross-coupling. Additionally, many of these are terminal alkynes that can participate as substrates in the Sonogashira cross-coupling reaction. All of thes...

consortin, connexin sorting protein
Synonyms C1orf71, PPP1R64
Species Human (163882) , Species Mouse (226744) , Species Rat (498297) , Species chicken (421487) , Species dog (611848) , Species domestic cat (101088971) , Species cow (541076) , Species Horse (100054634) , Species sheep (101115637) , Species naked mole-rat (101721862) , Species domestic guinea pig (100730837)
Summary: Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]

New Building Blocks for Chemical Biology

Matthias Junkers, Ph.D. Product Manager matthias.junkers@sial.com Modern automated synthesis protocols allow the fast and effi cient production of biopolymers like peptides and even proteins, or oligonucleotides. In recent years, even the automated synthesis of complex carbohydrates has been describ...

Building Blocks for Introducing Post-translational Modified Amino Acids

The Novabiochem® product line has always been at the forefront of the development for methods for the synthesis of peptides containing PTMs, being the first company to provide effective building blocks for synthesis of phosphorylated peptides, and sulfotyrosine and methylated arginine containing pep...

Lautens Chiral Building Blocks

Aldrich ChemFiles 2010, 10.1, 4. Dr. Daniel Weibel Dr. Daniel Weibel Product Manager Email:daniel.weibel@sial.com Professor Mark Lautens and his group at the University of Toronto have developed a powerful catalytic asymmetric ring opening reaction enabling the production of highly functionalized hy...

Azide Building Blocks for Chemical Ligation

Dr. Matthias Junkers, Product Manager Chemoselective ligation strategies are a key success factor for chemical biology research. Ligation techniques open pathways to fully synthetic large peptides and even proteins. They have proven to be valuable for peptide cyclization. Beside peptide synthesis, c...

Spirocyclic Building Blocks for Assembly of Innovative Scaffolds

Spirocyclic modules containing four-membered rings are currently of growing interest to discovery chemists. Sigma-Aldrich is pleased to offer a suite of spirocyclic building blocks in collaboration with Professor Dr. Erick Carreira and SpiroChem that includes assorted spiro[3.3]heptanes1 and spiro[3...

AldrichCPR Building Blocks

We are now partnering with select third party chemical suppliers to offer an extended line of building blocks and synthetic reagents for our customers. We have over 3000 of our partners' key products in stock and available, right off the shelves of our warehouse — making ordering from these dependab...

Protected Carbohydrate Building Blocks for More Efficient Syntheses

Related Links • Technology Spotlight Index • Carbohydrate Synthesis Categories • Carbohydrate Biochemistry • Glycobiology Introduction to Carbohydrate Chemistry Carbohydrates and their biologically active glycoconjugate analogs are emerging as an important class of biomolecules. Despite the growing ...

Degrader Building Blocks for Targeted Protein Degradation

An emerging strategy in drug discovery to access difficult-to-treat diseases is targeted protein degradation. While traditional small-molecule or antibody drugs may only allow access to ~20% of the proteome, degradation techniques may open the door to the other 80%.1 The molecules used in these appr...

Building Blocks for SuFEx: The Next Click Reaction - Organic Building Blocks

LiteratureSulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry (Angewandte 2014)Sulfonyl Fluorides (SuFEx): A New Click ReactionSulfonyl Fluorides allow for the rapid inclusion of building-block type moieties into Lead compounds. The “Click II” reaction is, like its Alkyne...

Building Blocks for HIV Protease Inhibitors - HIV Protease Reagents & Envelope Proteins

Protease inhibitors are an important class of totally synthetic drugs for the treatment of HIV. They are "peptoids" or "peptido-mimetics" (similar to peptides) that bind and block the active site of the proteinase enzyme necessary for HIV replication, thus stopping the AIDS virus from developing. Th...

Building Blocks - Chemical Synthesis

Building blocks are the basic components for organic synthesis. Sigma-Aldrich offers a market-leading range of building blocks including functionalized heterocycles, carbonyl compounds, nitrogen and oxygen compounds, halogenated compounds, alkynes, azides, and fluorinated compounds.Meet Synthia Retr...

Building Blocks and Chiral Small Molecules from Liverpool ChiroChem - Organic Building Blocks

Sigma-Aldrich Online Catalog Product List: Building Blocks and Chiral Small Molecules from Liverpool ChiroChem

Building Blocks - C-H Activation

Sigma-Aldrich Online Catalog Product List: Building Blocks

Building Blocks - Liquid Crystals

Sigma-Aldrich Online Catalog Product List: Building Blocks

Building Blocks - New Products for Chemical Synthesis

Sigma-Aldrich Online Catalog Product List: Building Blocks

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Fluorinated Building Blocks - Building Blocks

Aldrich Chemistry is proud to offer customers a vast offering of fluorinated building blocks, including trifluoromethyl (TFM), difluoromethyl (DFM), triflate, pentafluorosulfanyl, perfluorinated, and F-tagged substituents, as well as fluorinated organometallic substrates and fluorination reagents. F...

Degrader Building Blocks with Sulfuryl Reactivity - Degrader Building Blocks

Sigma-Aldrich Online Catalog Product List: Degrader Building Blocks with Sulfuryl Reactivity

Degrader Building Blocks Contact Form

Design the perfect PROTAC® - learn about what is new with the PROTACs offering. Please fill in the form below. Fields indicated by a * are mandatory. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Degrader Building Blocks - Chemical Biology

Degrader Building Blocks for Targeted Protein DegradationAn emerging strategy in drug discovery to access difficult-to-treat diseases is targeted protein degradation. The molecules used in these approaches are often called protein degraders, such as proteolysis targeting chimeras (PROTAC molecules),...

Spirocyclic Building Blocks - Carreira Spirocyclic Building Blocks

Sigma-Aldrich Online Catalog Product List: Spirocyclic Building Blocks

Chiral Building Blocks - Asymmetric Synthesis

Browse Sigma-Aldrich's Chiral Building Blocks to find products in Complex Molecules, Heterocyclic Building Blocks, Organic Building Blocks