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746 matches found for cancer

The Scepter™ Cell Counter Performs with High Precision and Speed Across Multiple Cell Lines

Introduction Counting cells is often a necessary but tedious step for in vitro cell culture. Consistent cell concentrations ensure experimental reproducibility and accuracy. Cell counts are important for monitoring cell health and proliferation rate, assessing immortalization or transformation, seed...

Silica-coated Gold Nanoparticles: Surface Chemistry, Properties, Benefits and Applications

In the past few decades, research and commercial use of gold nanoparticles has rapidly expanded into fields extending from biomedical engineering1 to photovoltaics.2 Most applications take advantage of the excellent optical properties of gold nanoparticles, which can be fine-tuned by varying their s...

Carcinogen Selector - Endocrine System - Adrenal Gland

The Carcinogen Selector gives researchers the ability to select carcinogens by the mouse organs that they promote cancer in. The tool includes over 750 carcinogens that target 35 specific organs across 9 biological systems. Step 1: Select a biological system. Step 2: Use the mouse model to select an...

Skin Cancer and Immunohistochemistry Webinar

Webinar Title: Skin Cancer and Immunohistochemistry Skin cancer is by far the most prevalent cancer. Each year, approximately 3.4 million people in the US alone are diagnosed with some form of skin cancer. Skin cancer can be highly treatable if it is detected and classified early, and this detection...

Fluorescent Silica Nanobeads: Properties and Applications

Fluorescent nanobeads offer great potential for many applications in both basic and applied research. In the recent past, scientists have been offered a wide range of technical solutions in fluorescence imaging, enabling a significant advancement in fields such as microscopy and diagnostics. However...

SILu™Prot Accurate Internal Standards in Quantitative MS

• We recently developed a novel collection of Stable Isotope-labeled (SIL) full length proteins designed to be used as mass spectrometry internal standards for quantitative proteomics. • These standards are spiked at the initial stage of the analytical workflow, thus significantly minimizing variati...

Avocado (Persea americana) | Plant Profiler

Synonyms / Common Names / Related Terms Abokado, aguacate, ahuacate, ahuacatl, alligator pear, avocado pear, Avocato, Persea americana, Persea americana var. drymifolia Blake, Persea gratissima, Persea leiogyna, Persea nubigena var. guatamalensis L., Persea persea, Laurus persea. Mechanism of Action...

Carcinogen Selector - Endocrine System - Clitoral/Preputial Gland

The Carcinogen Selector gives researchers the ability to select carcinogens by the mouse organs that they promote cancer in. The tool includes over 750 carcinogens that target 35 specific organs across 9 biological systems. Step 1: Select a biological system. Step 2: Use the mouse model to select an...

Complete Solutions for IVD Lateral Flow Immunoassay Development

Simplify immunoassay development and manufacture with a partner who understands the IVD market Accelerate your time to market with fit-for-use products which offer the quality, consistency, and documentation necessary for every step of your IVD development and manufacturing needs. Proven expertise i...

mutated in colorectal cancers
Synonyms MCC1
Species Human (4163) , Species Mouse (328949) , Species Rat (307449) , Species sheep (101121522) , Species naked mole-rat (101696544) , Species domestic guinea pig (100733895) , Species Zebrafish (100537329) , Species domestic cat (101097788) , Species cow (616704) , Species Horse (100064404) , Species dog (611208) , Species chicken (415603)
Summary: This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Protocol Guide: MTT Assay for Cell Viability and Proliferation

Introduction The MTT assay is used to measure cellular metabolic activity as an indicator of cell viability, proliferation and cytotoxicity. This colorimetric assay is based on the reduction of a yellow tetrazolium salt (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide or MTT) to purple ...

MILLIPLEX® Multiplex Assays for Cancer Biomarker Detection using Luminex® Technology

Biomarker detection multiplex assays for cancer research Measure biomarkers in your cancer research with MILLIPLEX® multiplex assays. For the full listing, download our Analyte Quarterly brochure. • Ready to Order? Customers in the United States, Denmark, Finland, Italy, Norway, Portugal, Spain • Re...

Carcinogen Selector - Endocrine System - Ear Zymbal's Gland

The Carcinogen Selector gives researchers the ability to select carcinogens by the mouse organs that they promote cancer in. The tool includes over 750 carcinogens that target 35 specific organs across 9 biological systems. Step 1: Select a biological system. Step 2: Use the mouse model to select an...

Protease Inhibitor Cocktails References

Our portfolio of protease inhibitor cocktails are frequently cited in peer-reviewed scientific literature, suggesting their superior quality and excellent track record. This page lists a sampling of those research papers. Other citations are available under the specific product pages for each of our...

Met

The Met family of receptor tyrosine kinases (RTKs) contains two members in mammals, referred to as Met and Ron. Met is the receptor for hepatocyte growth factor/scatter factor (HGF/SF), while Ron is the receptor for macrophage stimulating protein (MSP). In the adult, Met is predominantly expressed i...

Authenticated Liver Cancer Cell Lines for Cancer Research

Amongst liver cancers, the incidence of hepatocellular carcinoma (HCC) is increasing and has a high mortality rate. Chronic hepatitis B- or hepatitis C-induced cirrhosis is the leading risk factor for HCC. For reasons that are not entirely known, males may be three to five times more likely than fem...

Human Random Control DNA Panels for use as reference standards

Human Random Control DNA Panels for use as reference standards in routine assays. Together with ECACC, we have teamed up to provide researchers with control populations of human genomic DNA for gene regulation and quantitative PCR research. Collaboration to Provide Human Genomic Control DNA View Pre...

Stem Cell Culture Basics: Media, Cell Lines and Culture Reagents

Stem cells have the unique ability to self-renew or to differentiate into various cell types in response to appropriate signals. These properties provide stem cells with unique capabilities for tissue repair, replacement, and regeneration. Accordingly, human stem cells are of special interest in med...

Khat (Catha edulis) | Plant Profiler

Synonyms / Common Names / Related Terms Abyssinian tea, African salad, Arabian-tea, bushman's tea, cat, cathine, cathinone, Catha edulis, Celastraceae (family), Celastrus edulis, chat, chaat, gat, herbal ecstasy, kat, kus es Salahin, miraa, oat, phenylpropanolamine, qat (Yemen), qat, qut, somali tea...

Carcinogen Selector - Integumentary System - Subcutaneous Tissue

The Carcinogen Selector gives researchers the ability to select carcinogens by the mouse organs that they promote cancer in. The tool includes over 750 carcinogens that target 35 specific organs across 9 biological systems. Step 1: Select a biological system. Step 2: Use the mouse model to select an...

Epigenetics Overview - A portfolio of products for each step of your Epigenetic research workflow.

Epigenetics is a term coined to describe changes that are not mutation based but can still be passed on from generation to generation. Genes that are activated or repressed without any change in DNA sequence are epigenetically controlled. Epigenetic modifications are stable, but potentially reversib...

Carcinogen Selector - Reproductive System - Prostate

The Carcinogen Selector gives researchers the ability to select carcinogens by the mouse organs that they promote cancer in. The tool includes over 750 carcinogens that target 35 specific organs across 9 biological systems. Step 1: Select a biological system. Step 2: Use the mouse model to select an...

Development and Manufacturing Highly Potent APIs

SAFC’S leading position in the fast-growing Highly Potent Active Pharmaceutical Ingredients (HPAPI) market includes conjugation of HPAPIs to antibodies for exciting new anti-cancer drugs. HPAPIs are proven to be effective at much smaller dosage levels than traditional APIs, but their potent characte...

Immunology

Multiplex immune biomarkers and cytokine assays Measure biomarkers of inflammation and immune response with MILLIPLEX® multiplex assays. For the full listing, download our Analyte Quarterly brochure. • Ready to Order? Customers in the United States, Denmark, Finland, Italy, Norway, Portugal, Spain •...

Study Cancer with the CellASIC® ONIX Microfluidic Platform

Cancer cell transformation represents the epitome of dynamic cell behavior. Unprecedented genomic changes, metabolic reprogramming, microenvironment alterations, unchecked replication, and amazing feats of transmigration accomplished by a once mundane quiescent cell. The need for controlled dynamic ...

Carcinogen Selector - Endocrine System - Harderian Gland

The Carcinogen Selector gives researchers the ability to select carcinogens by the mouse organs that they promote cancer in. The tool includes over 750 carcinogens that target 35 specific organs across 9 biological systems. Step 1: Select a biological system. Step 2: Use the mouse model to select an...

Accurate Expression Profiling of Very Small Cell Populations

Background: Expression profiling, the measurement of all transcripts of a cell or tissue type, is currently the most comprehensive method to describe their physiological states. Given that accurate profiling methods currently available require RNA amounts found in thousands to millions of cells, man...

Affinity Chromatography Antibodies

We have prepared product lists for commonly used protocols from Cold Spring Harbor Protocols. View the entire protocol on BioSupplyNet.com. Selected Protocol from "Molecular Cloning: A Laboratory Manual," Third Edition, Joseph Sambrook, David W. Russell. Removal of Cross-reactive Antibodies from Ant...

Silver and Iron Stains

Bone marrow is the main site of iron utilization in the body, where it is incorporated into hemoglobin during red blood cell formation. Under normal conditions, iron deficiency rarely happens. Loss of iron from the body mainly occurs from chronic bleeding due to ulcers, cancer or in females by menst...

NEKs

The Nek protein kinase subfamily is named after the NIMA protein kinase of Aspergillus nidulans. Loss of NIMA function results in arrest at the G2/M boundary of the cell cycle despite activation of Cdc2. NIMA is necessary for the nuclear import of Cdc2 at the start of mitosis, and also for the const...

Elispot assays: State-of-the-art tools for functional analysis of cellular immunology

Abstract Under optimal conditions, the enzyme-linked immunosorbent spot (Elispot) assay enables visualization of multiple secretory products from a single responding cell. Thus, the Elispot provides both qualitative (type of immune protein) and quantitative (number of responding cells) information. ...