Changes will be taking place on on June 5, 2021 that include visual and functional updates.
All registered users will be prompted to reset their password the first time logging in to the new site.To ensure a smooth transition, please have access to and verify your current email address and password associated with your login profile prior to June 5, 2021. For additional details, click here

Duolink® PLA – Protein Detection Technology

Inside every cell, there is a breakthrough waiting to be uncovered. The chance to change the origin of a human disease or discover the tell-tale sign of an irregular protein-protein interaction requires a powerful investigative tool and a streamlined approach. Rely on Duolink® (proximity ligation assay) PLA to amplify your protein signals by 1000x and allow you to visually detect proteins and their interactions, all within a native cell. Our straightforward method provides:

  • Visual protein interactions – both stable and transient
  • Endogenous protein detection – no overexpression or genetic manipulation
  • High specificity – use of two antibodies/probes eliminates false positives
  • Single molecule sensitivity – rolling circle amplification makes proteins visible
  • No special equipment needed – standard immunofluorescence methods
  • Publication-ready results – compare image results from indirect methods (Co-Ip/WB)

Uncover the opportunities in your protein detection research with amplified performance and visual results.

 How does Duolink® PLA work?

 Protein Detection Resources


  • Protein-Protein Interaction
  • Post-Translational Modification
  • Low Abundant Proteins
  • Protein Localization
  • Digital Quantification

Product Search

Ready to begin your experiment? View our
list of Duolink® PLA products to get started.

Primary Antibodies

Explore our selection of PLA-qualified primary antibodies to use in your next Duolink® assay.