Sweet Poison – TraceCERT® CRM Solution for Tutin

By: Matthias Nold, Product Manager, Reference Materials

Tutin is a toxic oxygenated sesquiterpene occurring in the tutu plant (genus coriaria) that is found in New Zealand. It is responsible for poisoning through contaminated honey, when honeybees collect honeydew produced by sap-sucking vine hopper insects that feed on the tutu plant. Therefore, the Australia New Zealand Food Standards Code has set a maximum level of tutin of 0.7 milligrams per kilogram for honey and honey combs.1

We present a new TraceCERT® certified reference material of Tutin as a 20 ppm solution in acetonitrile, suitable as a calibrant for chromatographical methods such as LC/MS. This product is produced in accordance with ISO/IEC 17025 and ISO Guide 34 accreditation and is traceable to NIST SRM through quantitative NMR measurement of a concentrated stock solution in deuterated acetonitrile. The final CRM is then produced by gravimetrical dilution to the final concentration. Accelerated and real time stability tests as well as homogeneity tests have been performed by LC/MS and have been taken into account for the extended uncertainty of the CRM (see Figure 1).

Cause effect diagram


Product No. Description
80718 Tutin solution 20 μg/g in acetonitrile, certified reference material, TraceCERT®