Metal Organic Frameworks (MOFs)

Metal-organic frameworks (MOFs) are materials in which metal – to-organic ligand interactions yield porous coordination networks with record-setting surface areas surpassing activated carbons and zeolites. The applications of MOFs include storage and separations of gases, sensors, catalysis and others.1

MOFs are usually prepared under solvo- or hydrothermal conditions in pure N,N-diethylformamide or N,N-dimethylformamide, which slowly decompose upon heating and generate bases capable of deprotonating organic linker molecules. The latter react with metal salts and produce 3D meta-organic networks. A typical approach to MOF synthesis is depicted in
Figure 1.2

Figure 1. Typical approach to the preparation of MOFs
(Fig. 1, MM 4.4)

Metal salts, solvents and MOF linkers, suitable for the preparation of high performance MOF-177 3, UMCM-150 4, NOTT-101 5 and many others, are listed in the table below.


Dr. Channing Ahn of California Institute of Technology wrote to us about BTB (Product No. 686859) purchased from Sigma-Aldrich:

We're very happy with the results so far. Looks like your linker works well and has certainly saved us a lot of trouble in not having to make it ourselves!


MOF Constructor Tool




  1. Tools for designing high performance MOFs.
  2. Caskey, S. R; Matzger, A.J. Material Matters, 2009, 4, 111.
  3. Chae, H. K.; Siberio-Pérez, D. Y.; Kim, J.; Go, Y.; Eddaoudi, M.; Matzger, A. J.; O’Keeffe, M.; Yaghi, O. M. Nature, 2004, 427, 523.
  4. Wong-Foy, A. G.; Lebel, O.; Matzger, A. J. J. Am. Chem. Soc. 2007, 129, 15740.
  5. Lin, X.; Telepeni, I.; Blake, A. J.; Dailly, A.; Brown, C. M.; Simmons, J. M.; Zoppi, M.; Walker, G. S.; Thomas, K. M.; Mays, T. J.; Hubberstey, P.; Champness, N. R.; Schröder, M. J. Am. Chem. Soc. 2009, 131, 2159.


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